ABSTRACT
The central hypothesis of this proposal is that extracellular NE is taken up by macrophages and accumulates in both cytoplasmic organelles and the nucleus. NE activity degrades histone deacetylase 2 (HDAC2) and possibly other HDACS and Sirtuins resulting in increased acetylation of several targets including histone H3, High Mobility Group Box 1 (HMGB1) and nuclear factor kappa B (NFkB) p65, resulting in increased cytokine transcription and release of HMGB1 (AIM 1). Nuclear NE cleaves histone H3 and increases H3 citrulline resulting in chromatin decondensation and release of vital nuclear METs (AIM 2).
ABSTRACT
The goal of this study is to make a comparison between chronological and biological ages across the Italian and the Russian population. To serve this purpose we employ a measure of age recently introduced in the literature by Milevski (so-called Longevity-risk-Adjusted global age, hereafter L-RaG). Data for the Italian and the Russian population, split by regions, sex, and age groups have been collected for the years 2019 and 2020. Results show that there are significant differences between the chronological and the perceived ages for females and males across Italian regions. The difference exacerbates if we make a comparison between the North and the South regions. Looking at the Russian population, the gap appears extremely high for the North Caucasian area. Finally, we compare the median values of the gaps between the years 2019 and 2020. We found that in the latter year, the median values of the gap has been decreased. This could be attributed to the consequences of the Covid-19 pandemic. © 2021 IEEE.